![]() ![]() tissues and there are different kinds of cell deaths: reproductive (mitotic), apoptotic and G1 arrest. In biological effects of radiation to normal tissue there are different types of radiation damage to cells (i.e., single strand break-SSB, double strand break-double standard break (DSB), and other DNA lesions), different repair mechanism of cells vs. This model has been applied to both tumor as well as normal tissue. In practice, the model has claimed to provide a satisfactory and practical use for explanation of dose/fractionation and biological effect. Linear-quadratic model (L-Q model) of radiation effect was originally developed from consideration of subcellular bio-physical events ( 1, 2). Models and dose/volume recommendations are only as good as the data available. Care should be taken when applying models, especially when the clinical dose/volume parameters are beyond the range of data used to generate the model/parameters. In clinical practice of radiotherapy it is desirable to use models to estimate the complication risk. Keywords: Intraoperative radiotherapy (IORT) linear-quadratic model (L-Q model) high dose-high energy radiation high dose-low energy radiation Results: Due to the lack of inclusion and experimental verification of a significant number of factors, biological (i.e., no SLD repair, no cell repopulation between fractions, no reoxygenation, long delivery time and steeper dose fall off which affects RBE)/physiological and systemic (i.e., effects on immune systems), which impact on the effectiveness of high dose-low energy radiation, would make the L-Q model inappropriate for predictive modeling of normal tissue complications.Ĭonclusions: L-Q model is inappropriate to model biological effect of either high dose-high energy or high dose-low energy radiation. Methods: All pertinent literature addressing radiobiological aspects of L-Q formulism on high dose-high energy hypofractions and high dose-low energy radiation was reviewed and analyzed with regard to clinical utility. The purpose of this review is to evaluate whether the linear-quadratic model (L-Q model) is appropriate for predictive modeling and relative biological effectiveness (RBE) calculations of this new radiation. ![]() Objective: In recent years increasing number of patients are treated with intraoperative, high dose-low energy radiotherapy. Policy of Dealing with Allegations of Research Misconduct. ![]()
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